▶ Date: Nov.30 2017, 13:50~14:40

▶ Place: 233(2F), E7, DGIST

▶ Speaker: Guang-Zhong Yang / Max Planck Institute

▶ Title: Short-Term Synaptic Plasticity at a Glutamatergic Synapse

▶ Abstract

Synaptic Plasticity is held to be at the basis of most signal processing capabilities of the central nervous system. Long-term plasticity receives most attention by neuroscientists, since it underlies learning and memory. Short-term plasticity (STP), on the other hand, is not less important, since it mediates basic signal processing tasks, such as filtering, gain control, adaptation, and many more. My laboratory has studied STP at the Calyx of Held, a glutamatergic nerve terminal in the auditory pathway, which is large enough to be voltage-clamped in the ‘whole-cell mode’, using patch pipettes. STP is highly modulated by second messengers, such as Ca++ and diacylglycerol. In particular, it was shown that such modulators accelerate a process called ‘superpriming’, a slow transition of release-ready vesicles from a ‘normally primed’ state to a faster, ‘superprimed’ one (Lee et al. 2013; PNAS 110, 15079). Recently, we could demonstrate that this same process also mediates Post-Tetanic Potentiation, a medium-term form of synaptic plasticity (Taschenberger et al., 2016; PNAS 113, E4548-57). These findings will be discussed in the framework of literature data on various forms of short-term plasticity.

The Nobel Prize in Physiology or Medicine 1991

Source: "Erwin Neher - Facts". Nobelprize.org. Nobel Media AB 2014. Web. 24 Nov 2017. <http://www.nobelprize.org/nobel_prizes/medicine/laureates/1991/neher-facts.html>

▶ Editor: Sakmann Bert, Neher Erwin

▶ Title: Single-channel recording

▶ Edition: 2nd ed.

▶ Publisher: Springer 2009.

▶ Page: 700 p. 

▶ ISBN: 9781441912305

▶ Keyword: #Ion channels #Research #Methodology